Ubwoko I Ikizamini cya Diyabete, C-luminary biotechnology
| Umuti wa Chemiluminescent （Indwara za Autoimmune） | ||
| Urukurikirane | izina RY'IGICURUZWA | Abbr |
| AndikaⅠDiyabete | Antibody Anti-Glutamic Acar Decarboxylase Antibody | GAD |
| Antibody Anti-Islet | ICA | |
| Antibody Anti-Tyrosine | IA2 | |
| Anti-Insuline Autoantibody | IAA | |
| Anti-Zinc Abatwara 8 Antibody | ZnT8 | |
Glutamate decarboxylase (GAD) iboneka cyane muri neurone yo hagati no mu ngirabuzimafatizo zo mu binyabuzima hamwe n'abantu.Isoenzymes ebyiri (GAD85 na GAD67) zirahari, GAD67 iboneka gusa muri selile yumuntu B.Antibody Anti-Islet Antibody (ICA) niyo antibody yonyine ishobora gusenya cyane β ibice bigize selile.ICA nziza irashobora guhanura damage kwangirika kwakagari, bishobora gukoreshwa nkimwe mubimenyetso byerekana ibyago byinshi bya diyabete yo mu bwoko bwa 1.
Antibody Anti-Tyrosine Phosphatase (IA2), izwi kandi nka proteine-2 ya selile.Gutahura hamwe kurwanya antibody anti-protein tyrosine phosphatase antibody na antibody anti-glutamate decarboxylase irashobora kunonosora ibyiyumvo byo gusuzuma autoimmune T1DM.Abarwayi ba T1DM bafite antibody nziza irwanya proteyine tyrosine-fosifata bafite imiterere yubuvuzi bwimyaka yashize, inzira yigihe gito cyindwara, imikorere mike ya islet hamwe nibisabwa cyane na insuline idasanzwe.
Ubwinshi bwa Anti-Insuline Autoantibody (IAA) buragereranywa n’imyaka y’umurwayi, kandi ni bwinshi ku barwayi bafite munsi y’imyaka 5.Bikekwa ko iyo T selile ihuza gusenya selile B, ihinduka ryibice bitatu bya insuline ya insuline ihinduka, bikavamo antigenicite no gutanga ibisubizo bya antibody.IAA igaragara muri diyabete yo mu bwoko bwa 1 n’abarwayi ba preclinical, kandi igipimo cyiza cya IAA ni 40-50% ku barwayi ba diyabete yo mu bwoko bwa 1 basuzumwe, kandi IAA irashobora no kugaragara ku barwayi bakuze barwaye diyabete yihishe.IAA nziza irashobora kandi kugaragara muri syndrome ya insuline autoimmune n'indwara ya tiroyide, kandi abantu basanzwe nabo ni beza.Kubwibyo, IAA nziza ntabwo ifite umwihariko wo kumenya indwara yizinga, ariko irashobora kwerekana ubushake bwa autoimmune bwo kwandura indwara zirwa.
ZnT8A ni antibody nshya yavumbuwe kugirango isuzume diyabete yo mu bwoko bwa 1, igipimo cyayo cyiza kiri hafi ya antibody anti-GAD mugihe cyambere cya diyabete yo mu bwoko bwa 1.Kumenya ZnT8A bizafasha gusuzuma ibyago bya diyabete yo mu bwoko bwa 1 kandi bifite agaciro gakomeye ko kwisuzumisha no kumenyekanisha bene wabo bo mu rwego rwa mbere rw’abarwayi ba diyabete.
