Tumor Chemiluminescense Immunoassay Kit

Alpha-fetoprotein (AFP) ni ikimenyetso cyihariye kandi cyoroshye kubyimba kanseri yibanze y'umwijima.Iyo irenze 500ug / L cyangwa ibirimo bikomeza kuzamuka, birasobanutse.AFP ifitanye isano rya bugufi no kubaho kwa kanseri y'umwijima n'ibibyimba bitandukanye.Irashobora kwerekana ubwinshi bwibibyimba bitandukanye kandi irashobora gukoreshwa nkigipimo cyiza cyo kumenya ibibyimba bitandukanye.Kugeza ubu, ikoreshwa cyane cyane nk'ikimenyetso cya kanseri y'umwijima y'ibanze mu ivuriro hagamijwe gusuzuma no gukiza ingaruka za kanseri y'umwijima y'ibanze.

Carcinoembryonic antigen (CEA) ni glycoproteine ​​ya acide ifite ibiranga antigen yo mu nda ya kimuntu kandi ibaho muri selile endoderm.Ubuso bwa selile zitandukanye za kanseri ni poroteyine yubatswe ya selile.Yakozwe muri cytoplazme, isohoka hanze ya selile inyuze muri selile, hanyuma ikinjira mumazi akikije umubiri.CEA ikabije ikunze kugaragara muri kanseri yibara, kanseri yandura, kanseri yo mu gifu, kanseri y'ibere, kanseri ya tiroyide, kanseri y'umwijima, kanseri y'ibihaha, kanseri y'intanga, n'ibibyimba byo mu nkari.Ariko kunywa itabi, gutwita n'indwara z'umutima-damura, diyabete, diverticulitis yo mu mara, polyps rectal, colitis, pancreatitis, cirrhose y'umwijima, hepatite, indwara y'ibihaha, n'ibindi.

Ubwinshi bwa molekile ya CA125 iri hagati ya 200.000 na 1.000.000.Ni macromolecular glycoprotein ifite imiterere yimpeta kandi irimo 24% bya karubone.Nibintu bya glycoproteine ​​bisa na mucin kandi ni ibya IgG.Ubwinshi bwa CA125 mubantu bakuze bafite ubuzima buri munsi ya 35U / mL.Serumu CA125 muri 90% byabarwayi ifitanye isano niterambere ryindwara, bityo ikoreshwa cyane mugutahura indwara no gusuzuma neza.Urwego rwa CA125 muri 95% byabagore bakuze bafite ubuzima bwiza ruri munsi cyangwa rungana na 40U / ml, kandi hagomba kwitonderwa niba ruzamutse inshuro zirenga 2 agaciro gasanzwe.Byongeye kandi, CA125 irashobora kandi kuboneka mugupima serumu abarwayi bafite igituntu cya peritonite, kandi urwego rwa CA125 rwiyongereyeho inshuro nyinshi.Birashoboka ko indwara ya peritonite yigituntu nindwara ya pelvic inflammatory igomba kuvaho mbere yo kubagwa kanseri yintanga.

CA15-3 nikimenyetso cyingenzi cyingenzi cya kanseri yamabere.Urwego rwa CA15-3 muri 30% -50% by'abarwayi ba kanseri y'ibere rwiyongereye ku buryo bugaragara, kandi ihinduka ry'ibirimo rifitanye isano rya bugufi n'ingaruka zo kuvura.Nicyo kimenyetso cyiza kubarwayi ba kanseri yamabere kwisuzumisha no gukurikirana ibyabaye nyuma yo kubagwa no kureba ingaruka zikiza.Kwiyemeza gukomeye kwa CA15-3 bifasha mugutahura hakiri kare abarwayi bafite kanseri yibere ya II na III nyuma yo kuvurwa;iyo CA15-3 irenze 100U / ml, hashobora gutekerezwa indwara metastatike.

Carbohydrate antigen 199 (CA199) ni antigen ya oligosaccharide yibibyimba bifitanye isano na antigen, ikimenyetso gishya cyibibyimba, glycolipide kuri selile, ifite uburemere bwa molekile burenga 1000kD.Nibimenyetso byerekana kanseri yandura ivugwa kugeza ubu.Irahari muburyo bwa salivary mucin muri serumu.CA19-9 ifite ibyiyumvo byinshi kandi byihariye kuri kanseri yandura, kandi igipimo cyayo kiri hagati ya 85% na 95%, kandi kigabanuka hamwe no kunoza imiterere nyuma yo kubagwa.Serumu CA19-9 irashobora gukoreshwa nkigipimo gifasha gusuzuma indwara zifata ibibyimba bibi nka kanseri yandura na kanseri ya gallbladder.

Antigen yihariye ya prostate (PSA) ni polypeptide yumunyururu umwe urimo aside amine 237.Nibintu bya serine protease umuryango hamwe na tissue yihariye ya chymotrypsin-nkibikorwa.PSA yihariye tissue kandi ibaho gusa muri cytoplazme ya prostate yumuntu acinar na duct epithelial selile, kandi ntigaragarira mubindi selile.PSA ni ikimenyetso cyihariye cya kanseri ya prostate, ifite akamaro kanini mugupima kanseri ya prostate hakiri kare.

Ubuntu PSA bivuga igice cya PSA cyubuntu muri plasma kandi kidahambiriwe.Mubuvuzi, iri tandukaniro rikoreshwa mugupima kanseri ya prostate hakiri kare kubarwayi barwaye hyperplasia nziza.Kugeza ubu, igipimo cya fPSA / tPSA gikoreshwa cyane mu gufasha mu kumenya kanseri ya prostate na hyperplasia nziza.

Glycolytike enolase (2-fosifore-D-glycerate hydrolase), uburemere bwa molekile hafi 80 kD.Urwego rwa NSE ruri hasi mu baturage basanzwe cyangwa abarwayi bafite uburwayi bwiza, mu gihe urwego rwa neuron rwihariye rwa enolase (NSE) rushyirwa hejuru ku barwayi bafite indwara mbi ya neuroendocrine kandi ikaba ifatwa nk'ikimenyetso nyamukuru kibyimba cyo gukurikirana kanseri ntoya ya kanseri (SCLC) na neuroblastoma (NB).

Igice cya Cytokeratin 19 (CYFRA21-1) numunyamuryango muto muto wumuryango wa keratin kandi ukwirakwizwa cyane mubice bisanzwe byumubiri nka lamellar cyangwa epitelium squamous.Mu bihe by’indwara, igice cyacyo cya elegitoronike CYFRA21-1 gisohoka mu maraso kandi gishobora guhuza cyane na antibodiyite ebyiri za monoclonal KS19.1 na BM19.21, kikaba ari cyo kimenyetso cy’ibibyimba cyatoranijwe kugira ngo hamenyekane kanseri y'ibihaha itari ntoya.Ikimenyetso nyamukuru kuri cytokeratin 19 agace CYFRA21-1 nugukurikirana inzira ya kanseri yibihaha itari ntoya (NSCLC).

Indwara ya epididymis ya muntu 4 (HE4) ni iyumuryango wa proteine ​​ya tetra-disulfide (WFDC).HE4 ikoreshwa cyane cyane mugufasha mugusuzuma hakiri kare, gusuzuma itandukaniro, kugenzura imiti no gusuzuma progaramu ya kanseri yintanga ngore.Gutahura hamwe na kanseri ya kanseri ya antigen CA125 irashobora kurushaho kunoza ibyiyumvo byihariye no gusuzuma ibibyimba.Yerekanye kandi agaciro keza ko kwisuzumisha hamwe no gukurikirana amasomo yindwara muri kanseri ya endometrale na kanseri yubuhumekero.

Pepsinogen igabanijwemo ubudahangarwa muri pepsinogen I (PG-I) na pepsinogen II (PG-II).Urwego rwa serumu pepsinogen rugaragaza morphologie n'imikorere ya mucosa gastrica mubice bitandukanye: PG-I nigitekerezo cyo kumenya imikorere ya selile glande oxydeque, kwiyongera kwa acide gastricike byongera PG-I, kugabanuka gusohora cyangwa mucosal gastric gland atrophy PG -I yagabanutse ;PG-II yari ifitanye isano nini na gastric fundus mucosal lesions (ugereranije na gastric antrum mucosa), kandi kwiyongera kwayo kwari gufitanye isano na gastric fundus duct atrophy, gastric epithelial metaplasia cyangwa pseudopyloric gland metaplasia, na atypia;Kugabanuka gahoro gahoro igipimo cya PG-I / II cyajyanye no gutera imbere kwa mucosal atrophy.Kubwibyo, guhuriza hamwe kugereranya igipimo cya PG-I na PG-II birashobora kugira uruhare rwa "serologiya biopsy" ya fondasiyo ya gland mucosa kandi bigatanga agaciro keza ko kwisuzumisha mubikorwa byubuvuzi.

Indwara ya kanseri ya kanseri yitwa antigen (SCCA) ni TA-4 subcomponent squamous carcinoma antigen yakuwe muri kanseri y'inkondo y'umura.Ni glycoproteine ​​ifite uburemere bwa 48kDa kandi irimo byibuze ibice 14.Ingingo ya isoelectric yayo iri hagati ya 5.44 na 6.62.Ingingo ya isoelectric ni 6.62.SCCA nikimenyetso cyambere cyibibyimba bikoreshwa mugupima kanseri ya kanseri.Irashobora gukoreshwa nkigipimo gifasha kwisuzumisha hamwe nigipimo cyerekana ibimenyetso bya kanseri y'inkondo y'umura, kanseri y'ibihaha, na kanseri yo mu mutwe no mu ijosi.

β2-Microglobuline ni globuline ntoya ikorwa na lymphocytes, platine na polymorphonuclear leukocytes, hamwe na molekile ya 11800 hamwe na polypeptide yumunyururu umwe igizwe na acide 99 amine.Iyo imikorere y'impyiko ibangamiwe, urwego rwa β2-microglobuline ruzamuka bidasanzwe.Nkikimenyetso cyibibyimba bisanzwe, β2-microglobuline ikoreshwa cyane mugukurikirana imbaraga yibibyimba bitandukanye kugirango ifashe muguhitamo inzira yindwara cyangwa ingaruka zo kuvura.

Iyo umurwayi arwaye kanseri y'umwijima cyangwa aherekejwe na cirrhose y'umwijima, ikwirakwizwa rya ogisijeni mu ngingo z'umwijima ryangirika, kandi hypoxia itera imikorere y'umwijima kugabanuka, ari nako itera ihungabana rya vitamine K gufata cyangwa kuyikoresha, bikaviramo PIVKA II.PIVKA II ifite ingaruka nziza zo gusuzuma no kuvura mugutandukanya kanseri ya hepatocellular nizindi ndwara zumwijima.PIVKA II ni progaramu yigenga kandi isuzuma biomarker kugirango habeho kanseri y'umwijima, kandi ikoreshwa mugupima hakiri kare kuvura ibibyimba, gusuzuma indwara, uburyo bwo kuvura mbere yo gutangira, hamwe no guhanura abarwayi.

Ferritine ni poroteyine nini yisi yose ifite uburemere bwa molekuline ingana na 440 kDa igizwe na subunits 24 zidahuye.Igizwe na kote ya proteine ​​ya subunits 24 (apo-ferritine) hamwe nicyuma (ferritine mu mwijima no mu gihimba) kirimo impuzandengo ya 2500 Fe3 + ion.Hariho isano iri hagati yimyaka na serumu ferritine ku bagore, ariko ntabwo ari kubagabo.400 ng / mL ferritine ikoreshwa nkurwego rwumutwaro wicyuma mwinshi mumubiri irerekanwa mugihe urwego rwa ferritine ruzamutse kandi birashoboka ko hatabaho kugabanywa.Ferritin ivuga ko byagaragaye ko bifite agaciro mu kwemeza umwijima.

Gastrin irekura peptide (GRP), imisemburo ya gastrointestinal.Imbere ya poroteyine ifite aside aside amine 148, kandi nyuma yo gukuramo ibimenyetso bya peptide yerekana ibimenyetso, iratunganywa kandi ikabyara aside amine 27 GRP na 68 aminide aside amGRP.Bitewe nigice gito cyubuzima bwa peptide irekura peptide, iminota 2 gusa, ntibishoboka kuyimenya mumaraso.Hakozwe rero ubushakashatsi kugirango hamenyekane PRG, akarere ka karubasi-gasanzwe gakunze kuboneka mubwoko butatu bwa PRP igabanywa.Serumu progastrin-irekura peptide yerekanwe ko ari ikimenyetso cyizewe kubarwayi barwaye kanseri y'ibihaha ntoya (SCLC).proGRP na neuron yihariye ya enolase (NSE) ni molekile ebyiri zifitanye isano nuduce hamwe nibibyimba bikomoka kuri neuroendocrine.

Ahanini ikoreshwa mugukurikirana ingaruka zo kuvura kanseri yigifu na kanseri yintanga, serumu CA 72-4 irashobora gukoreshwa mugupima pancreatite, cirrhose yumwijima, indwara yibihaha, rubagimpande, indwara zabagore, indwara zintanga ngore, intanga ngore, indwara zamabere hamwe nindwara zifata gastrointestinal. n'izindi ndwara nziza.Ugereranije nibindi bimenyetso, CA 72‑4 ifite umwihariko wo gusuzuma indwara nziza.

CA50 ni acide sialic ester na acide sialic glycoprotein, mubisanzwe ntabwo ibaho mubice bisanzwe.Iyo selile zimaze kuba mbi, glycosylase irakora, bikavamo impinduka mumiterere ya selile glycosyl hanyuma igahinduka ikimenyetso cya CA50.I antigen ya carbohydrate antigen CA50 antigen idasanzwe idasanzwe yibibyimba yibibyimba, ifite antigenicite hamwe na CA199.

CA242 ni antigen ya karibiside ya karibiside isanzwe igaragara hamwe na CA50, ariko byombi bizwi na antibodi zitandukanye.Yakoreshejwe mubuvuzi mugupima ibibyimba bibi byigifu, cyane cyane kanseri yandura na kanseri yibara.Ugereranije na CA19-9 na CA50, igisekuru gishya cya CA242 gifite sensibilité kandi yihariye muri kanseri yandura, kanseri yandura na kanseri yinzira.

Gastrin ni imisemburo ya gastrointestinal isohorwa na selile G muri antrum gastric na mucosa duodenum mucosa.Muri gastrinoma, synthesis hamwe no gusohora kwa gastrine byiyongera cyane, biherekejwe no kwiyongera kw'isohoka rya acide gastricale.Ukurikije ibiranga gastrine nyinshi na aside gastricike nyinshi, irashobora gufasha mugupima no gusuzuma itandukaniro ryindwara, ikanakurikirana ingaruka zo gukiza.

Fosifatike ya Prostatike (PAP) ni glycoproteine ​​ikomatanya kandi ikarekurwa na selile ya prostate ikuze, yinjira mu mitsi ya seminal ikoresheje umuyoboro wa prostate, ikasohoka muri urethra.Urwego rwa serumu PAP ku barwayi barwaye kanseri ya prostate rwiyongereye ku buryo bugaragara, kandi urwego rwa PAP rwiyongereye hamwe na kanseri ya prostate.Birasabwa ko kumenya serumu PAP bifite akamaro kanini mubuvuzi bwa kanseri ya prostate.

Ikura ryindwara ya epidermal reseptor-2 (HER2), izwi kandi nka c-erB2, igizwe na adenine 922, cytosine 1,382, guanine 1,346, na thimine 880.ni imwe mu nyigo yize cyane kanseri y'ibere kugeza ubu.Gene ya HER2 ni ikimenyetso cyerekana ibimenyetso byo gukurikirana imiti ivura kandi ni intego y'ingenzi yo guhitamo ibiyobyabwenge mu kuvura ibibyimba.Serum HER2 ifitanye isano nuburemere bwibibyimba, HER2 yamateka, hamwe na lymph node kumurwayi wa kanseri yamabere, kandi birashobora kuba ibintu byigenga byerekana ibimenyetso, bishobora kugira ingaruka runaka kumikorere ya chimiotherapie cyangwa kuvura endocrine.HER2,

Uburemere bwa molekile ya tissue polypeptide antigen (TPA) ni 17.000-43.000, kandi igizwe na subunits eshatu, B1, B2 na C, kandi ibikorwa byayo ahanini muri B1.TPA ifite akamaro gakomeye mubuvuzi: kwiyongera kwa TPA mbere yo kwiyongera kubarwayi b'ibibyimba ni ngombwa cyane, ibyo bikaba akenshi byerekana nabi;nyuma yo kuvurwa, urwego rwa TPA rwongeye kwiyongera, byerekana ibibyimba byongeye kubaho;gutahura icyarimwe hamwe na CEA birashobora kunoza cyane Ukuri kwisuzumisha kanseri yamabere biterwa no gusuzuma itandukaniro riri hagati y ibisebe bibi kandi bitari bibi.