Ikizamini cya poroteyine zihariye, C-Luminary Biotechnology

Hariho poroteyine nyinshi muri serumu, ziva mu ngirabuzimafatizo, ni poroteyine zikora zirimo serumu, zikora imirimo itandukanye, indwara nyinshi zishobora gutera impinduka za poroteyine.Poroteyine zisanzwe zirimo ASO, RF, CRP, IgG, IgM, IgA, C3, C4, nibindi.

ASO isuzuma rifite agaciro kanini mugupima ubwoko bwanduye A streptococcus, kandi kuba ihari nibirimo birashobora kwerekana uburemere bwubwandu.ASO yatangiye kwiyongera nyuma yicyumweru 1 nyuma yubwoko bwa A streptococcus yanduye, igera ku mpinga nyuma yibyumweru 4-6, bimara amezi menshi.Iyo infection imaze kugabanuka, ASO yagabanutse kandi isubira mubisanzwe mumezi 6.Niba titer ya ASO itagabanutse, yatanze igitekerezo ko hashobora kubaho kwandura cyangwa kwandura indwara zidakira.Kwiyongera buhoro buhoro antibody ya titer ningirakamaro cyane mugupima.Kugabanuka gahoro gahoro ya antibody yerekana gukuraho indwara.ASO y'umuriro wa rubagimpande, glomerulonephritis ikaze, erythema nodosum, umuriro utukura na toniillillite ikabije yariyongereye cyane.

Kumenya RF bifite akamaro kanini mugupima, gutondekanya no kuvura indwara ya rubagimpande.Igipimo cyo kumenya RF mu barwayi barwaye rubagimpande ni nyinshi cyane.RF nziza ishyigikira kwisuzumisha kwa RA mugihe cyambere, nko gutandukanya RA na feri ya rubagimpande ku bagore bakiri bato.Gusuzuma RA idakora RA igomba kwerekeza kumateka.Mu barwayi ba RA, titer ya RF yari ifitanye isano neza nubuvuzi bw’abarwayi, ni ukuvuga ko titer yiyongereye hamwe no kwiyongera kwibimenyetso.

C-reaction proteine ​​bivuga proteine ​​zimwe na zimwe (proteine ​​acute) zizamuka cyane muri plasma mugihe umubiri wanduye cyangwa tissue zangiritse.CRP irashobora gukora yuzuzanya kandi igashimangira fagocytose ya fagocytes kandi ikagira uruhare runini, bityo igakuraho mikorobe zitera indwara kandi ikangirika, ingirabuzimafatizo ya nerotic na apoptotique mu mubiri kandi ikagira uruhare runini mu kurinda ubudahangarwa bw'umubiri.CRP imaze imyaka irenga 70 yizwe.Ubusanzwe, Bifatwa nkikimenyetso kidasanzwe cyo gutwika.Nyamara, mu myaka icumi ishize, ubushakashatsi bwerekanye ko CRP igira uruhare rutaziguye mu gutwika no gutera indwara ya ateriyose hamwe n’izindi ndwara zifata umutima, kandi ko ari zo zikomeye kandi zitera indwara z'umutima.

Immunoglobulin G (IgG) ni Immunoglobuline nyamukuru mu mubiri, bingana na 70 ~ 75% bya Immunoglobuline yose.Kugena ingano ya immunoglobuline muri serumu ni ingenzi cyane mugupima, kugenzura no gutangaza indwara zumwijima zidakira, indwara zandura, lymphocytose, myeloma nyinshi, immunodeficiency yibanze nayisumbuye.

Hafi ya 10% ya immunoglobuline muri serumu ni IgA, isa na IgG muburyo bwa monomer n'imiterere, ariko 10-15% bya IgA muri serumu ni polymeric.Ubundi buryo bwa IgA, bwitwa ibanga IgA, buboneka mumarira, ibyuya, amacandwe, amata, colostrum na gastrointestinal na bronchial.Kumenya immunoglobuline A muri serumu ni ingenzi cyane mugupima, kugenzura no gutangaza indwara zumwijima zidakira, indwara zandura, lymphocytose, myeloma nyinshi, immunodeficiency yibanze nayisumbuye.

Immunoglobulin M (IgM) nubwoko bwambere bwa immunoglobuline kandi immunoglobuline yonyine ikomatanyirizwa muri neonates.Muri serumu ikuze, ihwanye na 5 ~ 10% ya immunoglobuline ikwirakwizwa.IgM nyinshi muri serumu ni pentamers ya monomers eshanu.Uburemere bwa molekuline ya buri monomer ni 185KD, kandi buri monomer ihambiriwe numurongo wa J.IgM nigikorwa gikomeye cyuzuzanya gifite isano ikomeye ya bagiteri na selile yamaraso itukura kandi igira uruhare runini mukurinda kwandura G-bagiteri.Umubare wa immunoglobuline muri serumu ni ingenzi cyane mu gusuzuma, kugenzura no guhanura indwara zumwijima zidakira, indwara zandura, lymphocytose, myeloma nyinshi, immunodeficiency yibanze na kabiri.

Kuzuza C3 (Kwuzuza 3, C3) nigice cyingenzi cya sisitemu yo kuzuza kandi igira uruhare mubikorwa bya classique na bypass inzira.Kumenya C3 nikimenyetso cyingenzi mugupima indwara zumubiri nka lupus nephritis, reaction ya allergique no gutwika.Kubera ko C3 ikorwa numwijima, kugena C3 nabyo bifasha mugukurikirana indwara zikomeye zumwijima.Kumenya antibody anti-CCP birihariye cyane mugupima indwara ya rubagimpande ya rheumatoide kandi irashobora gukoreshwa mugupima hakiri kare RA.

Byongeye kandi, antibody anti-CCP ntabwo ari ikimenyetso cyo gusuzuma hakiri kare RA, ahubwo ni ikimenyetso cyerekana gutandukanya RA itera kandi idatera.Antibody-nziza abarwayi barashobora kwandura amagufwa akomeye kurusha abarwayi ba antibody.Gutahura hamwe antibodiyite za cRF na CCP bizamura cyane imyumvire yo gusuzuma.

Acide Sialic isanzwe iboneka nka oligosaccharide, glycolipide, cyangwa glycoproteine.Ubwonko bufite aside nyinshi ya sialic mumubiri wumuntu.Umubare wa acide sialic mubintu byijimye wikubye inshuro 15 ugereranije ningingo zimbere nkumwijima nibihaha.Acide Sialic ni ikintu cyingenzi kigize selile membrane glycoprotein, ifitanye isano nimirimo myinshi yibinyabuzima yibinyabuzima, kandi ifitanye isano rya bugufi na malignance selile, kanseri metastasis, gutera, gutakaza umubonano, kugabanuka kwa selile hamwe na antigenicity.s.