Poroteyine C Sisitemu Chemiluminescense Immunoassay Kit

Sisitemu C ya poroteyine C ikubiyemo proteine ​​C (PC), proteyine S (PS), trombomoduline (trombomoduline, TM, izwi kandi nka trombomoduline na protein C inhibitor).PC ikora poroteyine C ikora (APC) ikorwa na trombine, ishobora cyane cyane kudakora cofactors ya coagulation FVa na Fla;kubuza guhuza ibintu Xa kuri platine;guteza imbere fibrinolysis;PS ahanini igira uruhare rwayo mukwihutisha kudakora kwa Fla kubikorwa bya APC;TM yashyizwe kumurongo wa selile kandi mubyukuri ni reseptor ya trombine.Imbere ya Ca2 +, yihutisha gukora PC.

Poroteyine ikora C (APC) ikora nka "kubisabwa" anticoagulant, igabanya imiterere ya trombine.Kugabanya urugero rwa plasma ya APC cyangwa proteyine C (PC) bifitanye isano no kwiyongera kwingaruka ziterwa na tromboembolism.APC irerekana kandi imikorere ya cytoprotective kandi imikoreshereze yayo yo kuvura yasuzumwe muri sepsis ikabije kandi iri gusuzumwa mu ndwara nyinshi zifite ikintu gikomeye cyo gutwika.

Poroteyine ikora C (APC) ni poroteyine ya serine ikomoka kuri prursor yayo idakora, proteyine C (PC), ikora nka anticagulant naturel ikomeye itangiza ibintu Va na VIIIa.Igisekuru gisanzwe cya APC giterwa no guteranya neza kwa trombine, trombomoduline, PC hamwe na reseptor ya endothelial selile PC (EPCR) hejuru yutugingo ngengabuzima.Kubwibyo, impinduka iyo ari yo yose mu mikorere yiki giterane irashobora gutera kugabanuka cyangwa kwiyongera kwa generation ya APC ihindura ibyago bya trombose.

Hano haribimenyetso kubisekuru bya APC muri vivo.Niyo mpamvu, byavuzwe ko hari umubare munini wa peptide ya PC ikora hamwe na complexe ya APC hamwe na inhibitor physiologique.Imiterere ya physiologique ya PC mugutunganya amaraso aturuka kubisobanuro byiyongera ryibyago byo kwandura imitsi ya tromboembolism (VTE) bifitanye isano no kubura PC bikomoka kumurage ndetse no kurwego rwa APC ruzenguruka cyane.

Nubwo byakekwagaho kuba muri 60, ibikorwa bya Protein C na Protein S muri hemostasis byakorewe iperereza kandi bitangazwa kuva hagati ya za 80, hakurikiraho kuvumburwa na Thrombomoduline, selile endothelial selile membrane ifitanye isano na poroteyine, bigira uruhare runini rwa heamostatike.Izi poroteyine 3 zigira uruhare mu kugenzura trombogenezi no kurinda ibintu bya trombo-embolic.Iyo amaraso akozwe, ibimenyetso byose bya trombine bizenguruka bifatwa na Thrombomoduline muri microcirculation, bigatuma trombine ihinduka anticoagulant binyuze mubushobozi bwayo bwo gukora Protein C kuri Protein C ikora, ikora nka sentinel mu guhuza amaraso, muburyo bukomeye. hamwe na Protein S yubusa, kugirango uhagarike urubuga rushya rwose rwogukora amaraso, na cyane cyane kuzenguruka Ibintu bikora V na VIII.Poroteyine S ntabwo ikora nka cofactor ya Protein C ikora gusa, ahubwo ikora nka cofactor ya Tissue Factor Pathway Inhibitor.Mubyongeyeho, ifite imirimo imwe n'imwe yuzuzanya binyuze mu guhuza C4b-BP.Ubundi bushobozi bwa poroteyine C ikora ni ukugabanya ibikorwa bya fibrinolytike, kuko Inhibitor ya Protein C ikora kandi izwi nka Plasminogen Activator Inhibitor 3. Sisitemu ya Protein C-Protein S iba idakora neza imbere ya Factor V ihindagurika (Factor V-Leiden cyangwa izindi variants), zirwanya ingaruka zidakora.Izindi ndwara zifitanye isano niyi sisitemu zireba iterambere rya allo- cyangwa autoantibodies kuri Protein S cyangwa kuri trombine, ishobora kubyara ibibazo bikomeye bya trombotique ku barwayi banduye.Poroteyine C ikora (cyane cyane ku barwayi barwaye sepsis) cyangwa Thrombomoduline isabwa nk'imiti igabanya ubukana.Icy'ingenzi cyane, kuvuka kwa poroteyine C cyangwa poroteyine S bifitanye isano na trombotic yibintu bikunda kugaruka.