Pemphigus Chemiluminescense Immunoassay Kit

Pemphigus ni itsinda rya autoimmune ibibyimba byuruhu birimo uruhu na mucous membrane.Mubintu bitandukanye bitera indwara kandi umubiri ukora antibodiyite zihariye zirwanya hejuru ya desmosomes ya keratinocytes, bikavamo kurekura acanthocytes.Ukurikije uko ivuriro ribigaragaza, pemphigus irashobora kugabanywamo amoko ane: asanzwe, akwirakwira, yanduye na erythematous.Ubushakashatsi bwemeje ko desmoglein (Dsg) igira uruhare runini mu gutera indwara ya pemphigus.Antibody ya Dsg 1 na Dsg3 IgG byemejwe ko ari antibodi nyamukuru zitera indwara.Umubare w'indwara ya pempgigusvulgaris (PV) ni subtype yo hejuru kandi ikomeye cyane muri pemphigus.Kuba antibody irwanya Dsgl yerekana ko usibye kwerekana umunwa, irimo no gukomeretsa uruhu nizindi mucosa.Ubusanzwe PV itangirira mu kanwa (50% kugeza 70%) kandi ibaho mbere yizindi ndwara.Irashobora kuba ivuriro ryonyine ryerekana iyi ndwara.Kubwibyo, kubaga umunwa bigira uruhare runini mugutahura hakiri kare no gusuzuma PV hakiri kare.Kuba antibody irwanya Dsg1 na antibody anti-Dsg3 muri serumu yabarwayi ba pemphigus irashobora gukoreshwa kugirango hamenyekane fenotipiki yayo.Urwego rwa titer ya antibodi ebyiri hamwe na subtypes zabo zirashobora gukoreshwa kugirango umenye imiterere nibikorwa.Ibi bifite akamaro gakomeye kayobora mugusuzuma no kuvura pemphigus.

Paraneoplastique pemphigus (PNP) ni indwara yibasiwe na autoimmunite.Ivuriro ryerekana ibyangiritse byinshi.Ibimenyetso bikunze kugaragara ni stomatite yangiritse, isuri, ibisebe, kuva amaraso ya mucosa yo mu kanwa no mu minwa.Indwara ya PNP ntabwo isobanuwe neza.IP yemeje ko autoantibodies muri sera y'abarwayi imenya antigens zitandukanye za epidermal intracytoplasmic desmoplakin (umuryango wa plakin).Ubushakashatsi bwemeje ko antibody anti Dsg3 igira uruhare runini muri acantholysis no gushiraho ibisebe bya PNPs muburyo bwo kwimura pasiporo.

Bullous pemphigoid (BP) n'indwara y'uruhu rwa autoimmune, ikunze kugaragara ku bageze mu za bukuru barengeje imyaka 60.Antigen nyamukuru itera indwara ya BP ni igice cya desmosomes igice cyayo kandi ibyingenzi byingenzi ni antigen pemphigoid antigen (BPAGl, BP230) na antigen pemphigoid antigen 2 (BPAG2, BPl80, ubwoko bwa kolagen).Kumenya antibody yihariye ya BPl80 ifite sensibilité nini kandi yihariye, ishobora gukoreshwa nkigipimo cyingenzi cyo kuyobora imyitozo yubuvuzi.