Ibindi bipimisha Anticoagulant, C-Luminary Biotechnology

Lupus anticoagulant ni autoantibody irwanya fosifolipide yuzuye nabi, ubwoko bwa antibody ya antifosifolipide, ikunze kuboneka ku barwayi bafite indwara zifata uduce nka sisitemu ya lupus erythematosus.Kubera ko bwakozwe bwa mbere mu barwayi barwaye lupus erythematosus, yitwaga lupus anticoagulant.Byagaragaye ko bigaragara mu ndwara zitandukanye.Gukomeza ibintu bya lupus anticoagulant bifatwa nkibendera ryumutuku kubwo gukuramo inda bidasobanutse, kuvuka, kubyara gukura, gukura kwa arteriovenous trombose, indwara zitandukanye za trombofilique, nindwara zimwe na zimwe ziterwa na autoimmune. Lupus anticoagulant (LAC) ni immunoglobuline, cyane cyane IgG, a IgM cyangwa imvange yabiri.Ibikorwa byayo birinda umubiri cyane cyane muri IgM, kandi ni antibody ya antifosifolipide (harimo na anticardiolipine Iyo prothrombine ihinduwe na trombine, igomba kuba irimo porotrombine ikora fosifolipide, ibintu bya coagulation V, X, Ca2 +, nibindi, kandi LAC ni kubintu bigoye Muri fosifolipide, ihuza fosifolipide kandi idakora fosifolipide, ikongerera igihe cyo guhindura prothrombine muri trombine. Kubwibyo rero, birashobora kuba byiza cyane kubyita antibody anti-prothrombine, kandi kumenya ubushakashatsi bwibintu bya lupus anticoagulant bishobora kuba byiza cyane.

Gupima indwara mu mashami atandukanye yubuvuzi bifite akamaro kanini

Antithrombine III (antithrombine, AT III) ni kimwe mu bintu by'ingenzi birwanya umubiri wa muntu.Ni glycoproteine ​​ifite uburemere bugereranije bwa 58.2kD isohorwa na hepatocytes, kandi ni inhibitor ya serine protease.Muguhagarika ibikorwa bya trombine hamwe na coagulation factor VIIa, IX, X, XI na XII serine proteine, ikomeza kuringaniza amaraso mumubiri, kandi uruhare rwayo rugera kuri 70% yibikorwa byose bya sisitemu yo kurwanya anticagulation.Heparin irashobora gutera impinduka zifatika muri antithrombine, bigatuma byoroha na trombine guhambira, bishobora kongera cyane anticagulant ya antithrombine.

Kubura kwa AT ni impamvu isanzwe itera imitsi ya trombose na embolism yimpaha

Ibura rya Hereditary AT ni indwara yigenga ya autosomal yiganje, ubwiyongere bw'iyi ndwara bugera kuri 1/5000, ubwandu bukaba bumaze imyaka 10-25, kandi abarwayi bakunze kugira imitsi nyuma yo kubagwa, guhahamuka, kwandura, gutwita cyangwa kubyara.Thrombose, irashobora kwisubiramo

Kwiyongera kwa AT III kugaragara mugihe cyo kuva amaraso cyane nka hemofilia, leukemia, na anemia aplastique, ndetse no kuvura imiti igabanya ubukana.Mu kuvura anticoagulation, niba hakekwa kurwanya heparin ivura, AT III ibikorwa bishobora gukoreshwa kugirango hamenyekane.Kwipimisha kuri III bigomba kandi guhitamo gukurikiranwa mugihe cyo kuvura antithrombine no kugenzura ingaruka ziterwa na heparin.