Membranous Nephropathie (MN) Ikizamini
| Umuti wa Chemiluminescent （Indwara za Autoimmune） | ||
| Urukurikirane | izina RY'IGICURUZWA | Abbr |
| Membranous Nephropathie | Anti-Fosifolipase A2 Yakira Antibody | PLA2R |
| Antibody Anti-C1q | C1q | |
| Anti-trombospondin Ubwoko bwa I Imiterere irimo 7A Antibody | THSD7A | |
Membrane nephropathie (MN) yerekana nk'indwara yihariye ya autoimmune.Fosifolipase A2 yakira (PLA2R), iy'ubwoko bwa I transembrane reseptor, igaragazwa n'ubuso bw'isi.Mu barwayi ba nepropatique membrane hamwe na fosifolipase A2 reseptor antibody-nziza, ikwirakwiza antibody ya anti-fosifolipase A2 na antigen kuri reseptor ya fosifolipase A2 ihuza nk'urwego rukingira umubiri, ikabika kuri membrane yo munsi ya glomerular, igakora sisitemu yuzuzanya amaherezo ikangiza selile ya Sertoli hamwe na glomerular filtration barrière no gutera proteine yinkari.Urwego rwa PLA2R rufitanye isano rya bugufi nibikorwa byubuvuzi, nikimenyetso cyiza cyo guhanura inzira yindwara.Isesengura ryerekanye ko serumu PLA2R yari ifite sensibilité ya 73% kandi yihariye ya 83% mugupima indwara idasanzwe idasanzwe ya nepropatique, byerekana ko urwego rwa serumu PLA2R rufite agaciro ko kwisuzumisha mugihe cyibikorwa bya nepropatique idasanzwe.
C1q nikintu cyuzuzanya 1 (C1), uwatangije inzira ya kera yo kwuzuza ubudahangarwa bw'umubiri.C1q ikora nkibisubizo byambere subunit yibice byambere byuzuza C1.Ihuza na antigen-antibody immun-complexes, igira uruhare muburyo bwo kuzuzanya bwa classique ya classique hamwe na molekile ya C1r na C1s, ikanahuza no gukuraho ibintu byanduza, ibicuruzwa bya apoptotique hamwe nubudahangarwa bw'umubiri muri sisitemu ya macrophage.Iyo antibodiyide zirwanya C1Q zibaho, bizadindiza gukuraho ingirabuzimafatizo hamwe na selile apoptotique, bitera imbaraga z'umubiri gukora antibodi nyinshi, kikaba ari ikintu kiganisha ku bikorwa (systemic lupus erythematosus).
Andika Ⅰ platelet reaction protein 7A domaine (THSD7A) niyindi antigen ya podocyte itera MN nyuma ya reseptor ya fosifolipase A2 (PLA2R).Ivumburwa rya THSD7A na antibodies zayo byatumye habaho gusobanukirwa gushya kwa MN.Antibody ya serumu THSD7A irashobora guhuza antigen ya podocyte THSD7A kugirango ibe mumubiri urinda umubiri, biganisha kuri podocyte na proteinuria.Kimwe na antibody ya PLA2R, antibody ya THSD7A irashobora gukoreshwa mu kuyobora isuzuma, guhanura no gukurikirana indwara za MN.
