Indwara Yibihaha (ILD) Ikizamini

Indwara zifata interstitial ni itsinda rya diffuse parenchymal disorder zifitanye isano nuburwayi bukabije nimpfu.Ubumenyi bwagezweho mu myaka yashize bwatumye hashyirwa ahagaragara ibyiciro bishya bya pneumoniya idasanzwe, ukurikije amatsinda atatu: akomeye, adasanzwe kandi adashyizwe ahagaragara.Agashya k'ibyiciro bishya bituruka ku kuba bigoye gutondekanya ibice bishobora kuvurwa ukurikije ibyiciro byindwara.Idiopathic pulmonary fibrosis niyo yica cyane mu ndwara zifata ibihaha kandi ikagaragaza ubutumburuke bukabije mu myitwarire y’ubuvuzi.Hatanzwe ibyifuzo byinshi bya biomarkers kugirango hamenyekane inzira yindwara hamwe n’abarwayi bo mu matsinda bafite imiterere imwe mu bigeragezo by’amavuriro.Kwipimisha hakiri kare no gutondeka indwara nabyo ni ngombwa mubijyanye nizindi ndwara zifata ibihaha.Krebs von den Lungen-6 (KL-6) ni ubwoko bwa mucine transembrane irimo isukari ya acide acide acide, ifite uburemere bwa 200 KD.KL-6 igaragarira cyane cyane mubwoko bwa Ⅱ alveolar selile, cyangwa cytoplazme na selile ya selile ya bronchial epithelial selile.Igice cyo kuvuga cyabereye muri selire ya bronchioles na Clara selile cytoplasm cyangwa glande ya bronchial, pancreas, igifu, glande epithelial selile yumuryango, nibindi. , kuyobora iterambere rya fibrosis ya pathologiya.KL-6 irashobora guteza imbere ikwirakwizwa rya fibroblast yumuntu kandi ikarinda apoptose.Mu myaka yashize, ubushakashatsi bwinshi bwerekanye ko imvugo ya KL-6 ifitanye isano n’ibibyimba, indwara zimwe na zimwe z’ibihaha, ILD no kwangirika kwayo, gukomeretsa ibihaha bikabije n’izindi ndwara.Nkikimenyetso cya alveolar epithelial selile yangirika no kuvuka bundi bushya, KL-6 ikoreshwa muburyo bwihuse, bworoshye, bwubukungu, busubirwamo kandi butagutera, buruta uburyo bwa kera nkibihaha bihanitse cyane CT, alveolar lavage na biopsy yibihaha.Urwego rwa KL-6 muri serumu y'abarwayi rushobora gufatwa nk'ikimenyetso cyo kwirinda hakiri kare indwara y'ibihaha.