Hormone Chemiluminescense Immunoassay Kit

Imisemburo yimibonano mpuzabitsina igira uruhare runini muguhuza ibikorwa bisanzwe byubuzima bwumubiri wumuntu.Isuzuma rya hormone yimibonano mpuzabitsina rirashobora gukoreshwa muburumbuke, hypothalamic-pituitar-gonadal axis idakora neza, syndrome ya polycystic ovary syndrome, Down syndrome, ibibyimba byimyororokere nizindi ndwara gusuzuma no guhanura

Imisemburo itera Follicle (FSH) na hormone ya luteinizing (LH) isohoka na glande y'imbere ya pitoito.Imisemburo itera Follicle (FSH) ni iyumuryango umwe wa gonadotropine nka hormone ya luteinizing (LH), kandi igahuza kandi igatera imbaraga no guteza imbere imikorere n'imikorere ya gonado (ovaries na testes).Mu bagore, FSH ikora muri hypothalamic-pitoitar-ovarian igenzura, itera intanga ngore ya estrogene kugirango igenzure ukwezi.Kurekura paroxysmal ya FSH na LH muri pitoito gonadotropine bigengwa nibitekerezo bibi bya hormone steroid.Urwego rwa FSH rwerekana impinga hagati yimihango, ariko ntabwo ivugwa nka LH;kubera impinduka mumikorere yintanga nintanga za estrogene Kugabanuka, gucura FSH igera kurwego rwo hejuru.FSH mubagabo ikora kugirango itere intanga ngabo.

Testosterone (T) ikomatanyirizwa cyane na selile ya Leydig muri testis yumugabo, kandi ikanasohoka muke na glande ya adrenal na ovaries zumugore.Ibice birenga 98% bya testosterone ihujwe na alubumu na poroteyine ihuza imisemburo ya hormone nyuma yo kwinjira mumaraso, kandi umubare muto (2%) ubaho muburyo bwubusa (FT).Testosterone ya conjugated (Alb-T) idakora mubinyabuzima kandi byoroshye gutandukana muburiri bwa capillary, irekura T kugirango ikoreshwe.Alb-T na FT hamwe hamwe bita bioavailable testosterone.Ku bagabo, umurimo wingenzi wa testosterone ni uguteza imbere no gukomeza iterambere ryimiterere yimibonano mpuzabitsina ya kabiri yumugabo, gukomeza imikorere yimibonano mpuzabitsina y'abagabo, guteza imbere intungamubiri za poroteyine no gukura kw'amagufwa, no kongera metabolisme y'ibanze.Byongeye kandi, testosterone, hamwe na LH, itera intanga ngabo no gukura, kandi ifitanye isano nintanga ngabo hamwe na seminiferous tubule metabolism.Ku bagore, testosterone igira uruhare runini mu gukomeza gukura no gutera imbere bisanzwe ndetse no guhindura imikorere ya metabolike mugihe cy'ubugimbi ku bagore.

Dehydroepiandrosterone (DHEA) ni ikimenyetso cyimikorere ya androgeneque ya glande ya adrenal.Byinshi muri byo bibaho muburyo bwa sulfate (DHEAS), ihindurwa kuva DHEA nigikorwa cyimisemburo muri glande ya adrenal, kandi ikaba intangiriro yo guhuza testosterone na estrogene.Androstenedione isohorwa na gonado yumugabo nintanga ngore, hamwe na glande ya adrenal kubagabo nigitsina gore.Nibibanziriza testosterone na estrogene.Kubagabo, androstenedione ihindurwa testosterone ikoresheje 17β-hydroxydehydrogenase.Mu bagore, androstenedione ihinduka estrogene ikoresheje aromatase.

Estradiol (E2) ni imwe muri estrogene ikora cyane mu binyabuzima, cyane cyane isohoka mu ntanga ngore, kandi ikanasohoka ku rugero ruto na glande ya adrenal na testi y'abagabo.98% yamaraso azenguruka agomba guhuza albumin na SHBG, kandi umubare muto gusa ubaho mubuntu.E. ya ovulation.

Progesterone (Prog) ikoreshwa cyane cyane na luteal selile na plasita mugihe utwite, kandi niyo ibanziriza imisemburo ya testosterone, estrogene na adrenal cortex.Urwego rwa progesterone ikorwa n'abagabo n'abagore basanzwe ni ruto cyane, kandi nyuma yo gusohoka mu maraso, iba ihuza cyane na albumine na poroteyine ihuza imisemburo ya hormone kandi ikazenguruka mu mubiri.Urwego rwa Progesterone rufitanye isano no gukura hamwe na atrophy ya corpus luteum, ariko urugero rwa progesterone mu maraso ruba ruto mugihe cyo gutera intanga mu gihe cy'imihango y'umugore.Urwego rwo hejuru rwa progesterone rushobora kugaragara kumunsi ubanziriza intanga ngabo, kandi synthesis ya progesterone yiyongera cyane mugihe cya luteal.Mugihe cyimihango, uruhare runini rwa progesterone nuguteza imbere umubyimba wa endometrium, itera imiyoboro yamaraso na glande kwiyongera, bigatuma ururenda rworohereza gutera intanga ngore (urusoro).Mugihe cyo gutwita, progesterone ikomeza gutwita kandi ikabuza kugabanuka kwa myometrale.Progesterone irashobora kandi gukora kuri glande y’inyamabere kugirango iteze imbere iterambere rya acini y’inyamabere n’imiyoboro yo gutegura amashereka.

17α-hydroxyprogesterone (17α-OHP) ihindurwa na progesterone ikorwa na 17α-hydroxylase, cyangwa na 17α-hydroxypregnenolone ikorwa na 3β-hydroxysteroid dehydrogenase, ikorwa na cortex ya adrenal na gonad, ibikorwa byayo bya progesterone ni bike cyane.17α-OHP ni 21-hydroxylated kugirango ibe prursor compound S ya cortisol.17α-OHP muri serumu ikorana cyane na hormone yimibonano mpuzabitsina kugirango iteze imbere ingingo zinyuranye.

Imibonano mpuzabitsina ihuza globuline (SHBG) ni poroteyine itwara testosterone na estrogene (E2) mu maraso.SHBG ikorwa cyane cyane numwijima, kandi synthesis hamwe nisohoka ryayo bigengwa na estrogene kandi bigira ingaruka mbi kubinure byamavuta ya hepatike na cytokine ikongora.Serum SHBG yibanze hamwe na hormone, imikorere yumwijima, no gutwika.

Prolactine (PRL) ihagarikwa na selile adeno-pituito kandi irashobora guteza imbere imikurire, iterambere no gutandukanya ingirangingo zayo z’inyamabere z’inyamabere, kandi ni ikintu cyingenzi mu mikurire isanzwe y’ibere ndetse no konsa kw'abagore.Uruhare rwa estrogene, progesterone, glucocorticoid na insuline, PRL irashobora guteza imbere gukura kw'imitsi y’inyamabere no gusohora amata, kandi ikagira uruhare mu gukomeza gusohora amata mu gihe cyo konsa.Niba konsa bidakoreshejwe, urwego rwa PRL rusubira mubisanzwe mugihe cyibyumweru bitatu nyuma yo kubyara.Imbere ya testosterone, PRL irashobora guteza imbere iterambere rya prostate yumugabo na seminal vesicles, kandi ikongera ingaruka za LH kuri selile ya Leydig kugirango yongere synthesis.Mubyongeyeho, PRL ifite kandi imirimo yo kugenzura umusaruro wa adrenal ya andorogene no kugira uruhare mukwishura ibibazo.

Chorionic gonadotropine yumuntu (HCG) ni imisemburo ya glycoproteine ​​ikorwa cyane cyane ningirabuzimafatizo ya trophoblast.Igikorwa nyamukuru cya HCG ni uguteza imbere ihinduka rya ovarian corpus luteum muri corpus luteum yo gutwita, kugenzura imisemburo ya hormone steroid, no gukumira urusoro rwatewe intanga ngore.Mugihe cyo gutwita hakiri kare, amaraso yababyeyi ninkari HCG irashobora kwiyongera byihuse, kandi ikagenda yiyongera buhoro buhoro hamwe niterambere ryogutwita, igera kumyumweru 8-10, kandi igabanuka buhoro buhoro nyuma y amezi atatu yambere.

Imisemburo ya Mullerian (AMH), umwe mu bagize impinduka zikura zikura beta mu buryo budasanzwe, igira uruhare runini mu mikurire y’imyanya ndangagitsina kandi ni kimwe mu bimenyetso byingenzi bigize imikorere y’umugabo n’umugore.Ku bagabo, AMH ikorwa cyane na selile ya Leydig, itangirana na embryogenez kandi igakomeza ubuzima bwose;mu mikurire yumugabo, AMH itera kwangirika kwumuyoboro wa Mullerian gukora inzira yimyororokere yumugabo isanzwe ikura.Ku bagore, AMH ikorwa cyane na selile ovul granulosa selile, hamwe nimpinga yo hejuru itangira ubwangavu, hanyuma igabanuka gahoro gahoro uko imyaka igenda ihita ikamenyekana nyuma yo gucura.

Inhibin B (INHB) ni glycoproteine ​​ya dimeric, umunyamuryango wa factor ihinduka ryikura ryikura ryikirenga, agira uruhare mugutunganya intanga ngabo, gukura amagi, gukura, na ovulation, kandi ni cytokine ifitanye isano cyane nibisubizo byo gutwita.Ku bagabo, urwego rwa INHB mu maraso na plasma ya seminal rushobora kwerekana imikorere ya spermatogenic ya testis kandi ifitanye isano cyane nuburumbuke bwumugabo.Ku bagore, urugero rwa maraso INHB rufitanye isano rya hafi na endometriose, syndrome ya polycystic ovary (PCOS), na syndrome ya ovarian hyperstimulation (OHSS).

Estriol yubusa (uE3) ni estriol isohorwa numwijima wigitereko hamwe na plasita.Mu maraso y'ababyeyi n'inda mu maraso ku buntu.Gutwita bifitanye isano na plasma proteine ​​A (PAPP - A) ni macromolecular glycoproteine ​​ikorwa cyane na plasita na decidua.Mugihe cyo gutwita, PAPP-A ikorwa cyane na decidua ikarekurwa mukuzunguruka kwababyeyi, aho PAPP-A yibanda cyane hamwe no gutwita kugeza kubyara.Ubuntu beta-muntu chorionic gonadotropin （ubuntu-β-HCG） ni beta subunit ya HCG.uE3, PAPP - A, ubuntu-β-HCG bifite agaciro gakomeye mugupima mbere yo kubyara kugirango dusuzume syndrome ya Down hamwe nibindi bidasanzwe bya chromosomal mugihembwe cya mbere nicyakabiri.