Imikorere ya Hepatique Chemiluminescense Immunoassay Kit

Intego yo gusuzuma imikorere yumwijima ni ukumenya niba umwijima ufite uburwayi, urugero rwangirika rwumwijima no kumenya icyateye indwara yumwijima, guca imanza no kumenya icyateye jaundice.Hariho ibimenyetso byinshi bijyanye numurimo wumwijima, nka ALT, AST, Tbil, Dbil, ALP, γ-GT, CHE, TP, ALB, TBA, AMM, CG, AFU, ADA, PA, 5′-NT, MAO, LAP.

Alanine aminotransferase, ubwoko bwa transaminase, ikoreshwa kenshi mugupima ubushakashatsi bwindwara zumwijima kandi ni ikimenyetso cyerekana ububabare bwumwijima.Mu bikomere bitandukanye byumwijima, serumu (plasma) ALT irashobora kwiyongera cyane mbere yuko ibimenyetso byamavuriro (nka jaundice) bigaragara, mubisanzwe bigereranywa nuburemere no gukira kwindwara.

AST iboneka mu mubare munini winyama, nkimitsi yumutima, umwijima, imitsi ya skeletale nimpyiko.Urwego rwo hejuru rwa AST rufitanye isano no kwangirika kwimitsi ya myocardial na skeletale, ndetse no kwangirika kwumwijima.

AST na ALT ni ibimenyetso byerekana ibimenyetso byindwara zifata umwijima.

Bilirubin nigicuruzwa cyangirika cya hemoglobine, mugihe umubare munini wa gemoglobine wangiritse, ushobora kongera bilirubine yose muri serumu.Ivuriro uzamuke uzamuke hejuru ya bilirubin yuzuye kugirango urebe kuri virusi ya hepatite ya virusi, hepatite yubumara, imbere yumwijima cyangwa inzitizi ya biliary hanze yumwijima, indwara ya hemolytike, icteric ivuka.Kugena bilirubine yuzuye muri serumu irashobora gufasha mugupima indwara yumwijima no guhagarika biliary.Urwego rwo hejuru rwa bilirubin rutaziguye, ruzwi kandi ku izina rya conjugated bilirubin, rwerekana ko bilirubine isohoka mu nzira ya biliary nyuma yo kuvura hepatocyte.Kumenya neza bilirubin bifasha mugupima no gusuzuma itandukaniro ryubwoko bwa jaundice.

Kwiyemeza ALP bikoreshwa cyane mugupima ubushakashatsi bwindwara za hepatobiliary nindwara ziterwa na metabolism.Serumu ALP yiyongereyeho gato kandi igereranije muri hepatite ikaze (virusi nuburozi), cyane muri cholestasis iterwa na cirrhose na cholelithiasis, ndetse cyane cyane no guhagarika inzira ya biliary idasanzwe, kandi urwego rwo kuzamuka akenshi rufitanye isano neza nurwego rwo kuburizamo.

γ –glutamyl transfert ni nyinshi mu mpyiko, pancreas, umwijima no mu zindi ngingo, cyane cyane igira uruhare muri metabolism ya protein mu mubiri.Nibipimo byingenzi byubuvuzi bwa biohimiki mugusuzuma no gufasha kuvura indwara zumwijima / biliary na hepatite ya alcool.

Mu mavuriro, kugena ibikorwa bya serumu cholinesterase nuburyo bwingenzi bwo gufasha gupima uburozi bwa organophosifore no gusuzuma ibyangiritse byumwijima.

Poroteyine yuzuye igizwe na albumin na globuline.Kugabanuka kwintungamubiri za poroteyine zose zibona kuri proteinemia nkeya, harimo indurwe zigenda zitera imbere hamwe nu mwobo wumubiri urundanya amazi, inenge ya sintetike, imirire mibi, proteyine yakiriwe nimbogamizi yo gutegereza kuri bose bishobora gutera proteinemia nkeya.

Albumin, izwi kandi nka albumine, ikorwa na selile parenchymal selile kandi ni proteyine nyinshi muri plasma.Alb irashobora kugumana plasma colloid osmotic kandi ni poroteyine ihuza kandi itwara ibintu byinshi byingenzi muri plasma.Kugena umubare wa albumin bifasha mugupima no gukurikirana indwara zumwijima nka cirrhose.Byongeye kandi, irashobora kandi kwerekana ubuzima nimirire yabantu, bityo irashobora gukoreshwa mugupima indwara ziterwa nimirire mibi no gusuzuma prognoza yabarwayi bageze mu bitaro.

Umusaruro na metabolisme ya aside aside bifitanye isano rya bugufi n'umwijima.Urwego rwa aside aside ni ikimenyetso cyingenzi cyerekana igikomere cyumwijima, cyane cyane impinduka zikomeye zatewe na hepatite ikaze, hepatite idakira, gukomeretsa umwijima wa Ethanol na cirrhose.

Amoniya ni metabolite isanzwe mu mubiri.Bikomoka ku musemburo wo mu mara, gusohora impyiko ammonia, kubyara imitsi ya ammonia, n'ibindi. Ubwiyongere bwagaragaye muri koma ya hepatike, hepatite ikabije, ihungabana, uremia, uburozi bwa organofosifore, hyperammonemia ivuka hamwe na hyperammonemia y'abana bato.Kugabanuka mubiryo bya poroteyine nkeya, kubura amaraso, nibindi.

Serumu Cholyglycine (CG) ni imwe muri acide ya cholike ya conjugate ikozwe no guhuza aside ya cholike na glycine.Acide Glycholike nigice cyingenzi cya aside aside muri serumu mugihembwe cya gatatu cyo gutwita.Iyo selile yumwijima yangiritse, ubushobozi bwabo bwo gufata CG buragabanuka, bigatuma CG yiyongera mumaraso.

α -L-fucoidase ni enzyme ya lysosomal hydrolytic enzyme, igaragara cyane mu ngirabuzimafatizo z'umuntu, amaraso n'amazi yo mu mubiri, igira uruhare muri metabolism ya glycoproteine, glycolipide na oligosaccharide.Nibimwe mubimenyetso bya kanseri yibanze yumwijima.

Serumu ADA yiyongereye mu ndwara z'umwijima kandi zisanzwe muri jaundice zibuza, bityo birashobora kuba byiza kumenya jaundice ifatanije nibindi bipimo byerekana umwijima.

Prealbumin ni serumu glycoproteine ​​ikomatanywa na selile yumwijima.

PA igira uruhare mu gutwara tiroxine na retinol muri serumu.Kuberako igice cyubuzima ari kigufi cyane, gikoreshwa mukureba indangagaciro yo kwisuzumisha hakiri kare yerekana imikorere mibi yumwijima no kubura imirire, kandi kandi ni na fonctionnement fonctionnement reaction proteine ​​ikaze.

5 ′ -nucleotidase (5 '-NT) ni ubwoko bwa hydrolyase ya nucleotide, ibaho cyane mubice byabantu.Serumu 5-NT yiyongereye cyane muri jaundice ikumira.Serumu 5-NT ihinduka mubisanzwe ihwanye na ALP, ariko ntabwo ifitanye isano nindwara zifata.

Monoamine oxydease igira uruhare mu gukora fibre ya kolagen, bityo ikaba ikunze kuzamuka mu ndwara zimwe na zimwe za fibrotic.Kumenya ibikorwa bya enzyme muri serumu birashobora kwerekana ibikorwa byayo mubice bihuza kugirango wumve urugero rwa fibrosis.LAP ni protease nyinshi mu mwijima.

Igikorwa cya LAP cyariyongereye cyane hamwe na biliary intrahepatic na intrahepatic biliary stasis, cyane cyane muri biliary mbi, kandi ikomeza kwiyongera hamwe nindwara.Reagent ifite agaciro mugupima indwara zifata umwijima na kanseri yandura.