Sisitemu ya Fibrinolytike & DIC Ikizamini
| Igisubizo cya Coagulation |
| |
| Urukurikirane | izina RY'IGICURUZWA | Abbr |
| Sisitemu ya Fibrinolytike & DIC | Ibicuruzwa bitesha agaciro Fibrinogen | FDP |
| D-Dimer | D-Dimer | |
| Plasminogen | PLG | |
| α2- antiplasminase | α2-AP | |
| Inhibitor ya Plasminogen | PAI | |
| Von Willebrand Factor Antigen | vW Factor Antigen | |
Sisitemu ya fibrinolytike nigice cyingenzi cya sisitemu ya coagulation kandi igira uruhare runini mugukomeza gutembera kwamaraso nubusugire bwamaraso. Sisitemu ya fibrinolysis (fibrinolysis) igizwe nibice bine, aribyo plasminogene (plasminogen, plasminogen), plasmin (plasmin, plasmin), Lysogen ukora na fibrinolysis inhibitor.Inzira y'ibanze ya fibrinolysis irashobora kugabanywamo ibice bibiri, aribyo gukora plasminogene no gutesha agaciro fibrin (cyangwa fibrinogen)
Plasminogen (PLG): PLG ikomatanyirizwa n'umwijima.Iyo amaraso yuzuye, PLG yamamajwe kurubuga rwa fibrin kubwinshi.Mubikorwa bya T-PA cyangwa U-PA, PLG ikora muri plasminase, iteza imbere fibrin.Plasminogen ni imwe - urunigi β -globuline ifite uburemere bwa 80000 ~ 90000. Ihinduranya mu mwijima, mu magufa, eosinofile, no mu mpyiko hanyuma ikinjira mu maraso.Ku bantu bakuru, 10-20 mg / 100ml plasma.Ifite igice cyubuzima mumaraso yiminsi 2 kugeza 2.5.Biroroshye kwandikirwa kuri substrate yayo, fibrin.
Inhibitor ya plasminogen (PAI) na α2 anti-plasminogen inhibitor (α2-AP).PAI irashobora guhuza cyane na T-PA mukigereranyo cya 1: 1 kugirango idakora no gukora PLG.Ifishi nyamukuru ni PAI-1 na PAI-2.α2-AP ikomatanyirizwa n'umwijima.Uburyo bwibikorwa nuburyo bukurikira: α2-AP ihuza PL mu kigereranyo cya 1: 1 kugirango ibe igoye, ibuza ibikorwa bya PL.F ⅹ ⅲ ituma α2-AP ihuzwa na fibrin, igabanya ubukana bwa fibrin kuri PL.
Uburyo bwo kwangirika kwa Fibrin: PL itesha agaciro fibrin gusa ahubwo na fibrinogen.PL itesha agaciro fibrinogen kugirango itange ibice X, Y, D na E.Gutesha agaciro fibrin bivamo x ', Y', DD, E 'ibice.Ibi bice byose hamwe byitwa fibrin degradation produits (FDP).
Amaraso arimo fibrine, ikora kandi ikanatanga hydrolyz kugirango ikore ibicuruzwa byangirika byitwa "fibrin degradation produits."D-dimer nigicuruzwa cyoroshye cyo kwangirika kwa fibrin, kandi urwego rwiyongereye rwa D-dimer rwerekana ko hariho hypercoagulability na hyperfibrinolysis ya kabiri.Kubwibyo rero, kwibanda kuri d-dimer bifite akamaro kanini mugupima, gusuzuma neza no kumenya indwara ziterwa na trombotique.
von Willebrand (ibintu VIII ifitanye isano na antigen) ni glycoproteine nini iboneka muri plasma na endotelium kandi ihuza izindi poroteyine, cyane cyane ikintu cya VIII, ikarinda kwangirika kwayo vuba.Ntiboneka mu ndwara ya von Willebrand.Von Willebrand factor / factor VIII yibanze bigira uruhare runini mukuvura abarwayi bafite indwara ya von Willebrand.Igice cya von Willebrand igice kinini kigira akamaro kanini mugushikira hemostasis.
von Willebrand factor (VWF) nikintu kinini gifata glycoproteine isabwa kugirango platel yomekwe kuri subendotelium ahakomeretse ubwato, guteranya platine kugirango ibe icyuma cya platine, hamwe no guhagarika ibintu VIII (FVIII) mukuzenguruka.Kubura cyangwa inenge ya VWF biganisha ku ndwara ya Willebrand (VWD).Gusuzuma neza no kuranga VWD bisaba itsinda ryibizamini, harimo antigen ya VWF, igipimo cyibikorwa bya VWF, ibikorwa bya FVIII, multimers ya VWF, hamwe nupima ibipimo bya VWF.
Gukurikirana uturere twihariye twa VWF birashobora kandi kuba ingirakamaro mugupima.Ubwoko bwa 1 (inenge zingana), andika 2 (inenge yujuje ubuziranenge), n'ubwoko bwa 3 (kubura byuzuye) bigomba
gutandukanwa kugirango utange imiti ikwiye.
