Hagati ya Nervous Sisitemu Demyelination Antibodies IgG Ikizamini
| Umuti wa Chemiluminescent （Indwara za Autoimmune） | ||
| Urukurikirane | izina RY'IGICURUZWA | Abbr |
| Hagati ya Nervous Sisitemu Demyelination Antibodies IgG | Sisitemu yo hagati yo hagati ya Aquaporin 4 | AQP4 |
| Myelin Oligodendrocyte Glycoprotein | MOG | |
| Intungamubiri za Myelin | MBP | |
AQP4 ni ubwikorezi bwamazi bwihariye buboneka cyane muri astrocytes ya CNS, ariko no mu mpyiko (gukusanya umuyoboro), ibihaha (selile epithelial selile), igifu (selile parietal selile), epiteliya itandukanye ya glande na imitsi ya skeletale.AQP4, umuyoboro w'amazi mwinshi muri CNS, ni homotetramer yometse hejuru ya astrocytes ikoresheje proteine ya dystroglycan.Mu ndwara zose zitera indwara ya CNS, AQP4 niyo nzira yambere yo gutandukanya NMO na MS nizindi ndwara zanduza (umwihariko> 95%).Kubera ko MRIs z'abarwayi bafite umutwe wa NMO hakiri kare zidasanzwe, kwipimisha serologiya kuri AQP4 birashobora gufasha mukuyobora kuvura no guhanura hakiri kare.Igipimo cyiza cya AQP4 cyari 40% ku barwayi barwaye myelitis ndende (LETM) na 20% ku barwayi barwaye neurite optique (ON).Ku barwayi barwaye syndrome ya alobar (ON cyangwa LETM), positif ya AQP4 yerekana ko bishoboka ko 50% bishoboka ko umuntu ashobora kwandura CNS mu gihe cyumwaka umwe.
Indwara ya antibody ya MOG yagiye igaragara buhoro buhoro mu bantu mu myaka yashize.MOG (myelin oligodendrocyte glycoprotein) ni glycoproteine ifite uburemere bwa molekile kuva kuri 26 kugeza 28 kDa.Iragaragazwa cyane cyane kuri myelin yo hanze na oligodendrocytes yinyamabere y’inyamabere muri CNS kandi ikerekana uburyo bwo kubungabunga ibidukikije hejuru y’ibinyabuzima, aho ishobora kuba ikimenyetso cyerekana gukura kwa oligodendrocyte kandi ikagira uruhare mu bikorwa bitandukanye by’ibinyabuzima nko kugenzura amabwiriza. microtubule ituze, yuzuzanya inzira ya kera.Ku ikubitiro, abashakashatsi bagaragaje MOG nk'intego yo kurwanya antibody mu buryo bw'ingurube ya gineya ya autoimmune encephalomyelitis (EAE).
MBP igaragara muri serumu cyangwa CSF y'abarwayi ba MS, ariko ibyo ntibisobanura niba izo autoantibodies zifite uruhare rutaziguye mu gutera indwara ya MS demyelinating cyangwa ikorwa nyuma ya CNS yangiritse.Biragaragara ko antibody mu barwayi ba MS ishobora gukuramo MBP polypeptide ikanatera myelin kwangirika, kandi izo antibodiyite za myelin, cyane cyane mu bwoko bwa IgG1, zirashobora gukora ibintu byuzuzanya, bigatuma antibody iterwa na cytotoxicity.
