Ikizamini cyumutima

Ibimenyetso byumutima bikoreshwa cyane mugupima imvune ya myocardial.

cTnI na cTnT bigira uruhare runini mugutunganya imitsi yumutima yimitsi yumutima kandi ni ibimenyetso byihariye kandi byoroshye byerekana imvune ya myocardial.Myoglobin ibaho mumitsi ya myocardial na skeletale, ikarekurwa mumaraso mugihe imitsi ya skeletale hamwe no kwangirika kwa myocardial (infarction acute myocardial infarction (mi), kugenda cyane nindwara yimitsi, Muri infarction ikaze ya myocardial, serumu myoglobin yatandukanijwe nagaciro gasanzwe muri 2- Amasaha 3 yigihe cyambere cyububabare bwumutima kubera indwara ya myocardial tissue disorder, kandi igera ku giciro cyo hejuru mumasaha 6-9, hanyuma igaruka ku gaciro gasanzwe nyuma yamasaha 24. Ck-MB nimwe mubisomeri bitatu bya Creatine Kinase (CK ), izindi ebyiri ni CK-BB na CK-MM.Ubwoko bwa MB bubaho cyane cyane muri cardiomyocytes, bityo CK-MB ifite umwihariko wa myocardium. Muri Acute Myocardial Infarction (AMI), isohoka mumaraso. Ck-MB izamuka nyuma yamasaha 4-6 nyuma yindwara ya myocardial itangiye, igera kumasaha 24, ikagaruka mubisanzwe muminsi 3.

Lipoprotein ifitanye isano na fosifolipase A2 (LP-PLA2) ni ikimenyetso cyihariye cyamaraso cyerekana umuriro.Byagaragaye ko LP-PLA2 ari ibintu byigenga bitera indwara z'umutima n'umutima.Vuba aha byemejwe na FDA yo muri Amerika guhanura ibyago byo kurwara umutima wumutima hamwe nubwonko bwa ischemic, urwego rwa LP-PLA2 ni logarithmic igaragara neza ifitanye isano n'indwara z'umutima hamwe n'urupfu rw'amaraso.D-dimer nigicuruzwa cyihariye cyo gutesha agaciro fibrin monomer ihujwe na activateur XIII hamwe na hydrolyzed na enzyme ya fibrinolytique, nikimenyetso cyihariye cya fibrinolytike.Mugihe c'indwara ikaze ya myocardial, plasma ya DD irazamuka cyane.Poroteyine ya S100 yise kandi intungamubiri zo mu bwoko bwa nervine yihariye nk'ibimenyetso bya biohimiki byangiza ubwonko mu gukomeretsa ubwonko nyuma yigihe runaka, ariko kandi bifitanye isano rya bugufi n’ubwonko bwangirika bw’ubwonko hamwe na prognoz kandi, hamwe n’umutekano muke, gutahura ubwinshi bwabyo bifasha kumenya imiterere y’imitsi y’imitsi. ingano yindwara, ingaruka zo kuvura no guca imanza, nibindi.

Ubwoko bwa Cardiac fatty aside ihuza poroteyine (H-FABP) ni poroteyine nyamukuru itwara aside.Nibisanzwe byumutima cyane (ni ukuvuga, bigaragarira cyane cyane mubice byumutima), ariko kandi bigaragarira mubitekerezo bike mubice bitari umutima.Nyuma yo gutangira gukomeretsa ischemic myocardial, H-FABP irashobora kugaragara mumaraso mugihe cyamasaha 1 kugeza kuri 3 nyuma yo gutangira kubabara mugituza, hejuru kumasaha 6 kugeza 8 hanyuma ugasubira mubipimo bisanzwe bya plasma mugihe cyamasaha 24 kugeza 30.Nibimenyetso byizewe cyane byimvune ya myocardial, kandi urwego rwo hejuru rwa plasma H-FABP rushobora kugaragara mugihe cyambere cyindwara ya myocardial acute (0-3 h), kandi irekurwa ryayo ahanini biterwa no gukomeretsa kwa myocardial ischemia.PreproBNP ikomatanyirizwa muri cardiomyocytes hanyuma igahinduka molekile ibanziriza iyitwa proBNP.ProBNP noneho ibora muri physiologique ikora BNP, nigice cyo gutesha agaciro NT-probNP.Amabwiriza y’umuryango w’umutima w’ibihugu by’i Burayi asaba kunanirwa k'umutima arasaba BNP na NT-proBNP nk'ibimenyetso bya molekuline kugira ngo hamenyekane mbere yo gusuzuma indwara z'umutima.ST2 ni poroteyine yumutima ikorwa na cardiomyocytes munsi ya biomechanical stress.SST2 ikabije muri serumu irashobora gutuma myocardium idafite uburinzi buhagije bwa IL-33 mugihe cyo gukomeretsa imashini, bikaviramo myocardial kuvugurura no gukora nabi k'umutima.Kwiyongera gukabije kurwego rwa ST2 byerekana iterambere rihoraho rya fibrosis ya myocardial no kuvugurura, hamwe no gukaza umurego inzira yindwara yo kunanirwa k'umutima.ST2 ikoreshwa mugusuzuma kwa muganga abarwayi bafite HF ikaze kandi idakira, kugirango bayobore imiti ya HF.Icyemezo cya ST2 gifatanije na BNP cyangwa nT-probNP gishobora kunonosora ukuri ko gusuzuma ibizagerwaho n'umutima.