Allergen yihariye IgE Ikizamini

Indwara ya allergique ni uburyo umurwayi ahumeka cyangwa akarya ibintu birimo allergique (bita allergens cyangwa allergens, allergen) itera selile B z'umubiri gukora immunoglobuline E (IgE).Iyo antibodies za IgE zongeye guhura na allergène muri vivo, zihuza-na allergens hanyuma zihuza na reseptor ya FcεRI yo hejuru cyane hejuru ya selile ya mast na basofile, bikaviramo kwirundanya kwa FcεRI hamwe na selile ya mast hamwe na basofil.Mugihe cyo gukora, selile ya mast itesha agaciro kandi ikarekura histamine, umuhuza wumuriro wabitswe muri granules ya cytoplasmeque, na leukotriène, prostaglandine immunoreactive, cytokine na chemokine nka IL-4 na IL-5 byinjizwamo binyuze mumihanda ya acide arachidonic, cyangwa bikurura ibimenyetso byindwara ziterwa na allergique (cyangwa allergique reaction), nka asima ya allergique, umuriro wibyatsi, urticaria, rhinite ya allergique, eczema, dermatite ya allergique, conjunctivitis hamwe nudukorwa twa gastrointestinal.Kumenya ubwoko butandukanye bwa allergine yihariye ya antibodies ya IgE muri serumu irashobora gukoreshwa mugupima ubufasha bwo kumenya niba ibimenyetso bimwe na bimwe biterwa na allergie mubikorwa byubuvuzi.

Immunoglobulin IgE ni antibody ihuza ubwoko bwa I allergic reaction, kandi IgE yihariye ya allerge iboneka muri serumu yabarwayi ba allergique, bita IgE yihariye.Izo allergique kumata zifite IgE kurwanya allergens y'amata;izo allergic kuri artemisinin pollen zifite IgE kurwanya amabyi.Allergens yinjira mu mubiri kugirango itange umusaruro wa IgE yihariye, ihuza ingirabuzimafatizo na basofile, bigatuma umubiri winjira muburyo bwo gukangurira iyi allerge.Iyo allergen yongeye guhura, ihuza reseptor ya IgE kuri selile hanyuma igatera urukurikirane rw'ibinyabuzima, nyuma ikarekura abunzi batandukanye ba bioaktique bijyanye na allergique no gutwika, nka histamine.Kubera ko iyi antibody ishobora guhuza gusa na allerge, birakenewe gukoresha allerge isukuye aho kurwanya anti-IgE kugirango imenye.Hariho uburyo bwinshi bwihariye bwo gusuzuma IgE, nka ELISA, FEIA, na immunoblotting bikunze gukoreshwa mubikorwa byubuvuzi.