Allergen yihariye IgE (Ibigize) Ikizamini

Indwara ya allergique ni uburyo umurwayi ahumeka cyangwa akarya ibintu birimo allergique (bita allergens cyangwa allergens, allergen) itera selile B z'umubiri gukora immunoglobuline E (IgE).Iyo antibodies za IgE zongeye guhura na allergène muri vivo, zihuza-na allergens hanyuma zihuza na reseptor ya FcεRI yo hejuru cyane hejuru ya selile ya mast na basofile, bikaviramo kwirundanya kwa FcεRI hamwe na selile ya mast hamwe na basofil.Mugihe cyo gukora, selile ya mast itesha agaciro kandi ikarekura histamine, umuhuza wumuriro wabitswe muri granules ya cytoplasmeque, na leukotriène, prostaglandine immunoreactive, cytokine na chemokine nka IL-4 na IL-5 byinjizwamo binyuze mumihanda ya acide arachidonic, cyangwa bikurura ibimenyetso byindwara ziterwa na allergique (cyangwa allergique reaction), nka asima ya allergique, umuriro wibyatsi, urticaria, rhinite ya allergique, eczema, dermatite ya allergique, conjunctivitis hamwe nudukorwa twa gastrointestinal.Igenamigambi rya antibodiyite yihariye ya IgE muri serumu irashobora gukoreshwa mugufasha mugupima ibintu bitera allergie reaction mubikorwa byubuvuzi no guhitamo uburyo bukwiye bwo gukingira abarwayi.

Isuzuma ryibigize allerge nuburyo bushya bwo gusuzuma indwara za allergique, nazo zishingiye ku kumenya IgE yihariye.Bitandukanye na allergine ikabije ikoreshwa muburyo bwa gakondo bwo gusuzuma, gusuzuma ibice bya elucidation ikoresha allergie isanzwe / recombinant monomer allergie kugirango tumenye mbere na molekile zihariye zitera allergie, bigatuma gusuzuma indwara za allergique birushaho kuba ukuri.Irashobora gusuzuma neza ubwoko bwa poroteyine za allerge umurwayi allergique nuburyo allergique ye, bityo bigatanga urufatiro rwo gukomeza kwivuza kugiti cye.Gukoresha iki gice cya poroteyine ya allergique nka reagent ya desensitisation irinda ingaruka zishobora guturuka ku bice bya poroteyine bitari allerge cyangwa ibice bitari poroteyine bikomoka kuri allerge.Kumenya ibice bya Allergen birashobora kwerekana mubyukuri poroteyine zikangurira allergène, gukemura ibibazo byihariye byo kwisuzumisha biterwa na allerge, kandi bikamenya neza niba indwara ziterwa na allergique.Ubu buryo bushobora kumva neza uko allergen yambukiranya no guhanura izindi allergene zishoboka.